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Open the packaging, remove the silicone tip from the mouthpiece, and inhale from that end. Breath in and out naturally. There is no button or anything else you need to do.

Take 5-10 breaths whenever desired. There is no upper-limit on the amount of B12 you can have in any given day.

5-10 breaths is approximately 133 mcg of B12 (>5,000% Daily Value) and there are 30 such servings in each diffuser (30 x 133).

When it runs out, throw it away – you’ll know it’s out because no more vapor will come out and the LED will no longer light up.

According to the existing research on B12 inhalation:

“This simple form of therapy is not only effective, but safe and economical.”

–R.W. Monto & J.W. Rebuck, “Nasal Instillation and Inhalation of Crystalline Vitamin B12 in Pernicious Anemia,” AMA Arch Intern Med. Vol. 93, p. 219 (1954).

“There was no evidence of irritation at the time of inhalation. I personally examined the patients’ chests periodically, and I was not able to determine abnormal signs in the lungs.In addition to the clinical examination, we obtained periodic roentgenograms of the chest and they showed no change.”

“Inhalation of crystalline B-12 in physiological saline or lactose powder has, to do date, produced no objective or subjective evidence of toxicity or sensitivity at the pulmonary site.”

–F.J. Smith, R.W. Monto, J.W. Rebuck, “B12 Inhalation Therapy in Pernicious Anemia,” Trans Am. Clin. Climatol. Assoc. Vol. 64, p. 27 (1953).

We NEVER use nicotine, tobacco, vitamin E, THC, diacetyl, acetyl propionyl, vitamin E acetate, or propylene glycol in ANY of our products.

This is important because studies on mice have shown that products with nicotine caused cancer, but those without nicotine did not.

We only use: B12 (methylcobalamin), deionized water, USP-grade vegetable glycerin, and organic fruit flavors.

You should not use Breathe if you are sensitive to any of the ingredients, cobalt, or nickel.

It is also worth noting that the long-term effects of this technology, in general, are not fully understood.

A direct quote from an academic, peer-reviewed paper on the subject tackles this question:

“To further evaluate the efficacy of pulmonary absorption of the inhaled B-12 over and above the evidence afforded by the clinical and hematological response previously described, urinary excretion studies were performed… Upon oral administration of B-12 at dosages as high as 10,000 mcgm B-12 activity in urine has been shown to be less than 0.05 millimicrograms/ml. After inhalation of only 200 mcgm of B-12 in saline, B-12 activity in the urine reached the level of 0.26 millimicrograms/ml and following inhalation of approximately 500 mcgm of B-12 in a lactose powder B-12 activity in the urine rose to 0.134 millimicrograms /ml. Direct pulmonary instillation of 100 micrograms of crystalline vitamin B-12 by means of the bronchoscope resulted in a urinary excretion (9.76 millimicrograms/ml.) pattern equivalent to the intramuscular injection of 60-80 mcgm.”

–F.J. Smith, R.W. Monto, J.W. Rebuck, “B12 Inhalation Therapy in Pernicious Anemia,” Trans Am. Clin. Climatol. Assoc. Vol. 64, p. 27 (1953).

These measurements imply that inhalation can be order(s) of magnitude more absorbent than pills.

According to the National Institute of Health:
“Vitamin B12 is a nutrient that helps keep the body’s nerve and blood cells healthy and helps make DNA, the genetic material in all cells. Vitamin B12 also helps prevent a type of anemia called megaloblastic anemia that makes people tired and weak.”

The UK Vegan Society, the Vegetarian Resource Group, and the Physicians Committee for Responsible Medicine, among others, recommend that vegans either consistently eat B12-fortified foods or take a daily or weekly B12 supplement to meet the recommended intake.

In other words, getting enough vitamin B12 is very important.

A couple of our competitors have been rightly called-out for selling products that contain vitamins that can’t be effectively inhaled or are even downright dangerous. However, vitamin B12 is an ideal candidate for inhalation and the science goes back a half century.

Those studies found that inhaling B12 was very effective. We recommend reading the primary academic literature, like this one or any of the other sources listed at the bottom of our science page.

While vitamin B12 has become synonymous with energy products, it is worth noting that the science behind these claims is really only clear when it comes to people that have lower levels of B12. For those people, B12 can indeed play a role in higher energy levels, focus and sense of well-being, but for those that aren’t low in B12, the effects are less clear. Such people might not feel a difference from taking B12 at all.

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